Dr. Elliott J. Blumenthal
Taught by Dr. B.:
Welcome Class of 2015: orientation (to view click on blue link)
BIOLOGY ADVISING PAGE:
Link to Parkview Hospital Medical Technology Program- click to get information and application
Avian Flu Presentation- Lunch with a Scientist at Ft. Wayne Science Museum: Dec 9, 2006
Biology 100-- Introduction to Biology
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Biology 565 -- Immunology Lab
Biology 544 (schedule Fall 2004)--Principles of Virology Home Page 2004 Syllabus, Fall
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Journal Links of Interest
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American Cancer Society: (Perform search to find out about specific cancer)
Graduate School Search for Students interested in obtaining a PhD in Biology: Petersons.com
IPFW Pre-Med Club: Iinformation, Medical Schools, MCAT and much more !!
Research Interests:For longer than I am able to remember (this is an age-related problem) I have been interested in understanding how the immune system becomes altered with age. Beginning at sexual maturity of the animal, immune function starts to decrease, with visible signs showing during the last third of the organisms life span. These dysfunctions show as decreased immune reactivity to new antigens, decreased interleukin-2 (IL-2) production and secretion, and increased susceptibility to disease and cancer. I am examining possible mechanistic pathways that may change in an age-related fashion thereby leading to immune dysfunction, as well as how certain interventions may augment immune function in aging animals so that we might be able to enjoy a better quality of life as the inevitable age-associated senescent alterations begin to affect all of us. Towards this end we are examining certain biochemical and signal transduction pathways in immune cells to try to elucidate these age-related alterations (PKC and Tyrosine Kinase). We are currently examining the effects of dietary restriction in old aged mice and observing the effects of melatonin and ginseng on immunosenescence.
In addition to studying age-related alterations in immune system function, I have also been examining how environmental toxins (such as PCBs, dioxins and PAHs) affect immune function in rats, mice and fish, as well as examining signal transduction alterations in other organs, such as liver.Finally, I have examined immune responses in human patients who have prostate cancer and who have been treated by either surgical removal of the cancerous prostate or who have been given an alternate cryosurgical treatment. We have identified a significant augmentation in immune response following the cryosurgical procedure.
Publication of Interest: Deepta Atre and Elliott J. Blumenthal, 1998, "Melatonin: immune modulation of spleen cells in young, middle-aged and senescent mice", Mechanisms of Ageing and Development, 103: 225-268.
Techniques:The lab methods employed in the research include cell culture and proliferation studies, enzyme activities, ELISA assays, PAGE and Western Blot analysis of proteins.
To determine the immune status of an individual animal, immune response can be evaluated in a number of ways. In my lab we measure immune response through the use of proliferation assays of both T and B lymphocyte response to mitogenic stimulation, we examine cytokine (IL-2, IL-4, IL-10, IFN-gamma) production by the use of ELISA plate analysis. We perform enzyme activity analysis of protein kinase C (PKC) and Thymidine kinase (TK) by both radioisotope incorporation, Western blot and by ELISA analysis. We also have the capability of performing Flow Cytometric analysis of lymphocyte populations.
Teaching: My teaching interests fall into a number of specialized areas in Biology: Immunology, Virology, Cancer Biology, Microbiology and Biology Of Aging. Except for Biology of Aging, these courses are upper division level classes with prerequisites. Biology of Aging is a lower division class offered in conjunction with the Gerontology Certificate Program, and is offered as a General Education elective. The general course outline for each of these classes can be viewed by clicking on the appropriate link.
Lead Advisor- Biology
Assistant Dean for
Student Advising- College of Arts & Sciences
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Specifically, the FAR makes sure the student athlete
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Manual. In addition, the FAR can act as
student and Professor if a problem arises, although
will ultimately fall on the student to work out any
problems in the
classroom. IPFW is currently in the Summit
Conference. For information
concerning theSummit League check out the home page: http://www.thesummitleague.org/
For questions regarding my research or graduate studies at IPFW feel free to contact me through E-mail: BLUMENTH@IPFW.EDU
ADVISING Web Page:
BACK TO IPFW-BIOLOGY HOME PAGE: FOR FACULTY LISTINGS http://www.ipfw.edu/bio
the signal transduction/second messenger pathways involved in
activation and how we are
attempting to measure and determine why
immune function becomes altered with different types of
condidtions.transduction/second messenger pathways involved in
lymphocyte activation and how we are attempting to measure and
determine why immune function becomes altered with different
of environmental condidtions. (from Kuby, Immunology, 3rd
of ginseng on immune function
Dr. B. using highly technical, sophisticated and NIH patented, high powered microscope that enables one to see other worldly sights in immunology!